Min Li Organic Chemistry of Drug Degradation (Relié) Drug Discovery

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Vendeur: rarewaves-europe ✉️ (191.498) 98.1%, Lieu où se trouve: GU14 0GT, GB, Lieu de livraison: WORLDWIDE, Numéro de l'objet: 195900234551 Min Li Organic Chemistry of Drug Degradation (Relié) Drug Discovery.

Détails de l’annonce

Titre: Organic Chemistry of Drug Degradation
Condition: Neuf
Auteur: Min Li
Format: Relié
ISBN-10: 1849734216
EAN: 9781849734219
ISBN: 9781849734219
Publisher: Royal Society of Chemistry
Genre: Science Nature & Math
Sujet: Technology & Engineering
Année de publication: 2012
Date de publication: 2012-09-25
Description: The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.
Sujet: Anglais
Pays/Région de fabrication: GB
Item Height: 234
Item Length: 156.00
Poids: 604g
Série: Drug Discovery

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  • Condition: Neuf
  • Title: Organic Chemistry of Drug Degradation
  • Titre: Organic Chemistry of Drug Degradation
  • Auteur: Min Li
  • Format: Relié
  • ISBN-10: 1849734216
  • EAN: 9781849734219
  • ISBN: 9781849734219
  • Publisher: Royal Society of Chemistry
  • Genre: Science Nature & Math
  • Sujet: Anglais
  • Année de publication: 2012
  • Date de publication: 2012-09-25
  • Pays/Région de fabrication: GB
  • Item Height: 234
  • Item Length: 156.00
  • Poids: 604g
  • Série: Drug Discovery

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